TROMETHAMINE

Molecular Excipient

Mwt. LogP HBD HBA PSA RB CSP3
121.0 -2.3 4 4 87.0 3 1.0
UNII
023C2WHX2V
CAS
77-86-1
SYNONYMS
  • Tham
  • Tris(hydroxymethyl)aminomethane
  • Tromethamine
  • Nsc-6365
  • Trometamol
  • Trizma
  • Tris
  • Tris-Base
  • Trometamol [inn]
  • Tromethamine [usan]
  • Trometamol [ep]
  • Tromethamine [usp]
  • Trometamol [jan]
  • Tromethamine [orange Book]
  • Tham-E Component Tromethamine
  • Tromethamine Component Of Tham-E
  • Trometamol [mart.]
  • Tromethamine [mi]
  • Tromethamine [inci]
  • Tromethamine [hsdb]
  • Tromethamine [ii]
  • Tromethamine [usp-Rs]
  • Trometamol [who-Dd]
  • Tromethamine [vandf]
ZINC ID(s)
Availability
Present in 75 ZINC catalogs

Known Active Genes

There has not been any activity reported at 10μM or less for this excipient (per ChEBML)

Clinical Trials

This compound has been an intervention in the following clincial trials (per clinicaltrials.gov).
Code Date Title Phase Status
NCT02313675 2015-03-01 Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol for Carpal Tunnel and Distal Radius Fracture Surgeries Phase 4 Not Yet Recruiting
NCT02380001 2015-01-01 Analgesic Preoperative/Postoperative Dexketoprofen Trometamol in Third Molar Surgery Phase 4 Recruiting
NCT02160236 2014-11-01 Comparison of Postoperative Analgesic Efficacy of Intravenous Dexketoprofen Trometamol With Tenoxicam Phase 4 Recruiting
NCT02132468 2014-09-01 A Phase 2 Study of Fosbretabulin in Subjects With Gastrointestinal Neuroendocrine Tumors (GI-NET) and With Elevated Biomarkers Phase 2 Recruiting
NCT02178254 2014-08-01 Safety, Tolerability and PK 3-Period Crossover Study Comparing 2 Single Doses of ZTI-01 and MonurolĀ® in Healthy Subjects Phase 1 Completed
NCT02102516 2014-03-01 SPRIX in 0 to 11 Year-Old Patients Undergoing Open Surgical Procedures Phase 3 Recruiting
NCT02092012 2014-03-01 Comparison of Preemptive Analgesic Effects of Dexketoprofen Versus Dexmedetomidine on Abdominal Hysterectomy Patients Phase 4 Recruiting
NCT01471899 2013-10-01 Comparison Of Ketorolac Tromethamine Oral Drops Versus Naproxen For Moderate to Severe Back Pain Treatment Phase 3 Not Yet Recruiting
NCT02086097 2013-08-01 Dexketoprofen Trometamol in Postoperative Endodontic Pain Phase 4 Completed
NCT01471886 2013-06-01 Comparison Of Ketorolac Tromethamine Versus Naproxen For Moderate to Severe Back Pain Treatment Phase 3 Recruiting
NCT02004548 2013-05-01 Phase I Clinical Study of Metatinib Tromethamine Tablet Phase 1 Recruiting
NCT01904149 2013-05-01 Oral Treatment for Post-operative Gynaecological Pain With Dexketoprofen Trometamol and Tramadol Hydrochloride Phase 3 Completed
NCT01820897 2013-04-01 Efficacy of Fosfomycin-Trometamol in Urinary Tract Infection Prophylaxis After Kidney Transplantation Phase 4 Completed
NCT01902134 2013-04-01 Oral Treatment for Post-operative Orthopaedic Pain With Dexketoprofen Trometamol and Tramadol Hydrochloride Phase 3 Completed
NCT01799863 2012-06-01 Artificial Tears Versus Preservative Free Ketorolac Trometamol 0.45% for Acute Viral Conjunctivitis Phase 2/Phase 3 Enrolling By Invitation
NCT02000401 2012-05-01 Intranasal Ketorolac Tromethamine (Sprix) for Acute Pain of Interstitial Cystitis Flare of Pain Phase 4 Completed
NCT01558622 2012-03-01 Intraoperative Use of Dexketoprofen Trometamol, Pethidine Hcl, Tramadol Hcl and Their Combinations for Postoperative Pain Management in Laparoscopic Nissen Fundoplication Phase 4 Active, Not Recruiting
NCT02000388 2012-02-01 Intranasal Ketorolac Tromethamine (SPRIX) as a Short Term Pain Management of Post-Vasectomy Pain Phase 4 Enrolling By Invitation
NCT01488955 2012-02-01 Immediate vs. Conditional Use of Antibiotics in Uncomplicated Urinary Tract Infection (UTI) - ICUTI Phase 4 Completed
NCT01596166 2012-02-01 Intravenous Ketorolac and Metoclopramide for Pediatric Migraine in the Emergency Department Phase 4 Completed
NCT01436032 2011-10-01 Efficacy, Safety and Tolerability Study of N1539 in Subjects After Abdominal Laparoscopic Surgery Phase 3 Terminated
NCT01291472 2011-06-01 Disposition of Intravenous Ketorolac Phase 4 Completed
NCT01305213 2011-03-01 Bevacizumab With or Without Fosbretabulin Tromethamine in Treating Patients With Recurrent or Persistent Ovarian Epithelial, Fallopian Tube, or Peritoneal Cavity Cancer Phase 2 Active, Not Recruiting
NCT01307020 2011-02-01 Analgesic Effect of Different Combinations of Dexketoprofen Trometamol With Tramadol Hydrochloride in a Model of Moderate to Severe Pain Phase 2 Completed
NCT01542190 2011-02-01 Comparison of Topical Ketorolac 0,4% Versus Placebo in Cataract Surgery Phase 4 Completed
NCT01258309 2010-12-01 Safety and Efficacy of Olopatadine Hydrochloride/Ketorolac Tromethamine Ophthalmic Solution Compared With Olopatadine Hydrochloride Ophthalmic Solution in Patients With Seasonal Allergic Conjunctivitis Phase 3 Completed
NCT01023724 2009-12-01 A Comparison of Post Phacoemulsification Aqueous Flare in Patients Using Ketorolac 0.45% 2 Times Daily (BID) and Bromfenac 0.09% 2 Times Daily (BID) Phase 4 Completed
NCT01001806 2009-10-01 A Comparison of Peak Aqueous Penetration of Acuvail (Ketorolac 0.45%), Xibrom (Bromfenac 0.09%), and Nevanac (Nepafenac 0.1%)in Patients Undergoing Phacoemulsification Phase 4 Completed
NCT01021761 2009-10-01 A Comparison of Prostaglandin E2 (PGE2) Inhibition of Acuvail(Ketorolac 0.45%), Xibrom (Bromfenac 0.09%)and Nevanac (Nepafenac)in Patients Undergoing Phacoemulsification Phase 4 Completed
NCT00907114 2009-06-01 Topic Ketorolac Added to Panphotocoagulation in Proliferative Diabetic Retinopathy Phase 2 Completed
NCT00865540 2009-03-01 Effect of Anti-inflammatory Topical Prednisolone, Nepafenac and Ketorolac in Intra-operative Mydriasis in Facetectomies Phase 4 Active, Not Recruiting
NCT01015235 2008-12-01 Safety and Efficacy Study of KAI-1678 to Treat Subjects With Postoperative Pain Phase 2 Completed
NCT00621530 2008-03-01 Effect of Spinal Ketorolac on Mechanical Hypersensitivity After a Total Hip Replacement Phase 2 Terminated
NCT01365624 2008-02-01 Safety and Pharmacokinetics Study of Intranasal Ketorolac in Elderly and Nonelderly Adult Healthy Subjects Phase 1 Completed
NCT01365650 2007-12-01 Study to Assess the Absorption and Tolerability of Intranasal Ketorolac Tromethamine and to Assess the Effects of Oxymetazoline Hydrochloride and Fluticasone Propionate on the Absorption and Tolerability of Intranasal Ketorolac Tromethamine in Participants With Allergic Rhinitis Phase 1 Completed
NCT01351090 2007-10-01 Study of the Safety, Tolerability and Analgesic Efficacy of Multiple Doses of Ketorolac Tromethamine (IN) for Postoperative Pain Phase 2 Completed
NCT00483717 2007-07-01 Efficacy and Safety of Intranasal Ketorolac for the Acute Treatment of Migraine Phase 2 Completed
NCT01363076 2007-06-01 The Pharmacokinetics of Ketorolac Tromethamine Administered Intranasally (IN) for Postoperative Pain in Children Aged 12 Through 17 Years Phase 1 Completed
NCT01365611 2007-02-01 Open Label Study to Assess the Pharmacokinetics of Intranasal Ketorolac Tromethamine Following Fluticasone Propionate in Healthy Subjects Phase 1 Completed
NCT01363089 2007-01-01 Study to Assess the Pharmacokinetics of Ketorolac Tromethamine and to Assess the Effects of a Oxymetazoline Hydrochloride on the Pharmacokinetics of Ketorolac Tromethamine Phase 1 Completed
NCT01363063 2006-12-01 Study of the Tolerability of Ketorolac Tromethamine Following Intranasal Administration in Healthy Volunteers Phase 1 Completed
NCT00332774 2006-02-01 Nevanac 3-Month Safety Study With QID Dosing Phase 3 Completed
NCT01363050 2006-01-01 Study to Determine the Tolerability, Safety and Pharmacokinetics of Ketorolac Tromethamine by Intranasal Administration in Healthy Volunteers Phase 1 Completed
NCT00266786 2005-12-01 Safety and Efficacy of Multiple Doses of Intranasal Ketorolac in Postoperative Pain Following Major Abdominal Surgery Phase 3 Completed
NCT00405730 2005-11-01 Nepafenac 0.1% Eye Drops, Suspension Compared to Ketorolac Trometamol 0.5% Eye Drops, Solution and Placebo Phase 3 Completed
NCT01355588 2005-08-01 Tolerability, Safety and Pharmacokinetics of Four Formulations of Ketorolac Tromethamine in Healthy Volunteers Phase 1 Completed
NCT01356225 2004-02-01 A Single-dose Study of Intranasal Ketorolac in the Treatment of Pain Secondary to Dental Impaction Surgery Phase 2 Completed
NCT01347853 2003-06-01 Safety and Efficacy of Multiple Doses of Ketorolac Tromethamine Administered Intranasally for Postoperative Pain Phase 3 Completed
NCT01356212 2002-09-01 Assessment of Nasal Deposition and Clearance of Ketorolac Solution Administered Using the Valois Nasal Spray Device Phase 1 Completed
NCT01260883 2000-05-01 Ketorolac in Postoperative Infants: Pharmacokinetics and Safety Phase 3 Completed

(Browse) Purchasable Analogs in ZINC

Dosages

Route Formulation Per Unit Dose
Im - Iv Injectable 1.1%
Im - Iv Injection, Solution 1.21%
Intra-Arterial Injection 0.24%
Intramuscular Injection 0.1%
Intrathecal Injection
Intrathecal Solution
Intratracheal Suspension 0.24%
Intravascular Injection 1%
Intravascular Solution
Intravenous Injectable 1.2%
Intravenous Injection 1%
Intravenous Solution
Intravenous Solution, Injection 0.09%W/W
Iv(infusion) Injection 0.01%
Iv(infusion) Powder, For Injection Suspension, Lyophilized 1.21%
Iv(infusion) Solution
Iv(infusion) Solution, Injection 0.004%
Ophthalmic Solution 0.94%
Ophthalmic Solution, Drops 0.75%
Ophthalmic Solution, Gel Forming, Extended Release 0.8%
Ophthalmic Suspension, Drops
Rectal Solution
Respiratory (inhalation) Solution, For Inhalation 0.01%
Subcutaneous Injection 0.6%
Topical Gel 0.8%
Topical Solution 8.4%
Transdermal Gel 0.1%
Urethral Solution 0.12%
Oral Solution
Oral Capsule, Soft Gelatin 15MG
Oral Tablet

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Usage Over Time

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