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Indications And Usage Fosinopril Sodium And Hydrochlorothiazide Tablets Are Indicated For The Treatment Of Hypertension. These Fixed Dose Combinations Are Not Indicated For Initial Therapy. (see Dosage And Administration . ) In Using Fosinopril Sodium And Hydrochlorothiazide, Consideration Should Be Given To The Fact That Another Angiotensin-Converting Enzyme Inhibitor, Captopril, Has Caused Agranulocytosis, Particularly In Patients With Renal Impairment Or Collagen-Vascular Disease. Available Data Are Insufficient To Show That Fosinopril Does Not Have A Similar Risk (see Warnings: Neutropenia/agranulocytosis ). Ace Inhibitors (for Which Adequate Data Are Available) Cause A Higher Rate Of Angioedema In Black Than In Non-Black Patients (see Warnings: Head And Neck Angioedema And Intestinal Angioedema ).
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