Application Nr Approved Date Route Status External Links
ANDA040258 None Intramuscular None Google , Wikipedia , PubMed , DailyMed , Raw OpenFDA , ECHA , ToxNet , JECFA , FAO , 21 CFR

Indications and Purposes

Indications And Usage: Leucovorin Calcium Rescue Is Indicated After High Dose Methotrexate Therapy In Osteosarcoma. Leucovorin Calcium Is Also Indicated To Diminish The Toxicity And Counteract The Effects Of Impaired Methotrexate Elimination And Of Inadvertent Overdosages Of Folic Acid Antagonists. Leucovorin Calcium Is Indicated In The Treatment Of Megaloblastic Anemias Due To Folic Acid Deficiency When Oral Therapy Is Not Feasible. Leucovorin Is Also Indicated For Use In Combination With 5-Fluorouracil To Prolong Survival In The Palliative Treatment Of Patients With Advanced Colorectal Cancer. Leucovorin Should Not Be Mixed In The Same Infusion As 5-Fluorouracil Because A Precipitate May Form.

All Formulated Excipients (0 Total)

None

Active Ingredients ( 1 Total)

Name Structure ZINC ID(s)
1. Leucovorin Calcium LEUCOVORIN CALCIUM ZINC9212427

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