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Indications And Usage Clomipramine Hydrochloride Capsules Usp Are Indicated For The Treatment Of Obsessions And Compulsions In Patients With Obsessive-Compulsive Disorder (ocd). The Obsessions Or Compulsions Must Cause Marked Distress, Be Time-Consuming, Or Significantly Interfere With Social Or Occupational Functioning, In Order To Meet The Dsm-Iii-R (circa 1989) Diagnosis Of Ocd. Obsessions Are Recurrent, Persistent Ideas, Thoughts, Images, Or Impulses That Are Ego-Dystonic. Compulsions Are Repetitive, Purposeful, And Intentional Behaviors Performed In Response To An Obsession Or In A Stereotyped Fashion, And Are Recognized By The Person As Excessive Or Unreasonable. The Effectiveness Of Clomipramine For The Treatment Of Ocd Was Demonstrated In Multicenter, Placebo-Controlled, Parallel-Group Studies, Including Two 10-Week Studies In Adults And One 8-Week Study In Children And Adolescents 10 To 17 Years Of Age. Patients In All Studies Had Moderate-To-Severe Ocd (dsm-Iii), With Mean Baseline Ratings On The Yale-Brown Obsessive Compulsive Scale (ybocs) Ranging From 26 To 28 And A Mean Baseline Rating Of 10 On The Nimh Clinical Global Obsessive Compulsive Scale (nimh-Oc). Patients Taking Cmi Experienced A Mean Reduction Of Approximately 10 On The Ybocs, Representing An Average Improvement On This Scale Of 35% To 42% Among Adults And 37% Among Children And Adolescents. Cmi-Treated Patients Experienced A 3.5 Unit Decrement On The Nimh-Oc. Patients On Placebo Showed No Important Clinical Response On Either Scale. The Maximum Dose Was 250 Mg/day For Most Adults And 3 Mg/kg/day (up To 200 Mg) For All Children And Adolescents. The Effectiveness Of Clomipramine For Long-Term Use (i.e., For More Than 10 Weeks) Has Not Been Systematically Evaluated In Placebo-Controlled Trials. The Physician Who Elects To Use Clomipramine For Extended Periods Should Periodically Reevaluate The Long-Term Usefulness Of The Drug For The Individual Patient ( See Dosage And Administration ).
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