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Indications And Usage Captopril And Hydrochlorothiazide Tablets Are Indicated For The Treatment Of Hypertension. The Blood Pressure Lowering Effects Of Captopril And Thiazides Are Approximately Additive. This Fixed Combination Drug May Be Used As Initial Therapy Or Substituted For Previously Titrated Doses Of The Individual Components. When Captopril And Hydrochlorothiazide Are Given Together It May Not Be Necessary To Administer Captopril In Divided Doses To Attain Blood Pressure Control At Trough (before The Next Dose). Also, With Such A Combination, A Daily Dose Of 15 Mg Of Hydrochlorothiazide May Be Adequate. Treatment May, Therefore, Be Initiated With Captopril And Hydrochlorothiazide Tablets 25 Mg/15 Mg Once Daily. Subsequent Titration Should Be With Additional Doses Of The Components (captopril, Hydrochlorothiazide) As Single Agents Or As Captopril And Hydrochlorothiazide Tablets 50 Mg/15 Mg, 25 Mg/25 Mg, Or 50 Mg/25 Mg (see Dosage And Administration ). In Using Captopril And Hydrochlorothiazide, Consideration Should Be Given To The Risk Of Neutropenia/agranulocytosis (see Warnings ). Captopril And Hydrochlorothiazide May Be Used For Patients With Normal Renal Function, In Whom The Risk Is Relatively Low. In Patients With Impaired Renal Function, Particularly Those With Collagen Vascular Disease, Captopril And Hydrochlorothiazide Should Be Reserved For Hypertensives Who Have Either Developed Unacceptable Side Effects On Other Drugs, Or Have Failed To Respond Satisfactorily To Other Drug Combinations. Ace Inhibitors (for Which Adequate Data Are Available) Cause A Higher Rate Of Angioedema In Black Than In Non-Black Patients (see Warnings: Captopril: Head And Neck Angioedema And Intestinal Angioedema ).
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