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1 Indications And Usage Betapace/betapace Af Is An Antiarrhythmic Indicated For: • The Treatment Of Life Threatening Ventricular Arrhythmias ( 1.1 ) • The Maintenance Of Normal Sinus Rhythm In Patients With Atrial Fibrillation Or Flutter (Afib/afl) ( 1.2 ) Limitations Of Use • Avoid Use In Patients With Asymptomatic Ventricular Premature Contraction ( 1.1 ) • Avoid Use In Patients With Minimally Symptomatic Or Easily Reversible Afib/afl ( 1.2 ) 1.1 Life-Threatening Ventricular Arrhythmias Betapace/betapace Af Is Indicated For The Treatment Of Life-Threatening, Documented Ventricular Arrhythmias, Such As Sustained Ventricular Tachycardia (Vt). Limitation Of Use: Betapace/betapace Af May Not Enhance Survival In Patients With Ventricular Arrhythmias. Because Of The Proarrhythmic Effects Of Betapace/betapace Af, Including A 1.5 To 2% Rate Of Torsade De Pointes (Tdp) Or New Ventricular Tachycardia/fibrillation (Vt/vf) In Patients With Either Non-Sustained Ventricular Tachycardia (Nsvt) Or Supraventricular Arrhythmias (Svt), Its Use In Patients With Less Severe Arrhythmias, Even If The Patients Are Symptomatic, Is Generally Not Recommended. Avoid Treatment Of Patients With Asymptomatic Ventricular Premature Contractions [See Warnings And Precautions ( 5.2 )] . 1.2 Delay In Recurrence Of Atrial Fibrillation/atrial Flutter (Afib/afl) Betapace/betapace Af Is Indicated For The Maintenance Of Normal Sinus Rhythm (Delay In Time To Recurrence Of Afib/afl) In Patients With Symptomatic Afib/afl Who Are Currently In Sinus Rhythm. Limitation Of Use: Because Betapace/betapace Af Can Cause Life-Threatening Ventricular Arrhythmias, Reserve Its Use For Patients In Whom Afib/afl Is Highly Symptomatic. Patients With Paroxysmal Afib That Is Easily Reversed (By Valsalva Maneuver, For Example) Should Usually Not Be Given Betapace/betapace Af.
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