1 Indications And Usage Buprenorphine Transdermal System Is Indicated For The Management Of Pain Severe Enough To Require Daily, Around-The-Clock, Long-Term Opioid Treatment And For Which Alternative Treatment Options Are Inadequate. L Imitations Of Use Because Of The Risks Of Addiction, Abuse And Misuse With Opioids, Even At Recommended Doses, And Because Of The Greater Risk Of Overdose And Death With Extended-Release Opioid Formulations [See Warnings And Precautions ( 5.1 )] , Reserve Buprenorphine Transdermal System For Use In Patients For Whom Alternative Treatment Options (E.g., Non-Opioid Analgesics Or Immediate-Release Opioids) Are Ineffective, Not Tolerated, Or Would Be Otherwise Inadequate To Provide Sufficient Management Of Pain. Buprenorphine Transdermal System Is Not Indicated As An As-Needed (Prn) Analgesic Buprenorphine Transdermal System Is A Partial Opioid Agonist Indicated For The Management Of Pain Severe Enough To Require Daily, Around-The-Clock, Long-Term Opioid Treatment And For Which Alternative Treatment Options Are Inadequate. ( 1 ) L I Mitations Of Use Because Of The Risks Of Addiction, Abuse, And Misuse With Opioids, Even At Recommended Doses, And Because Of The Greater Risks Of Overdose And Death With Extended-Release Opioid Formulations, Reserve Buprenorphine Transdermal System For Use In Patients For Whom Alternative Treatment Options (E.g., Non-Opioid Analgesics Or Immediate-Release Opioids) Are Ineffective, Not Tolerated, Or Would Be Otherwise Inadequate To Provide Sufficient Management Of Pain. ( 1 ) Buprenorphine Transdermal System Is Not Indicated As An As-Needed (Prn) Analgesic. ( 1 )
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