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1 Indications And Usage Clindamycin Is A Lincosamide Antibacterial Indicated For The Treatment Of The Following: • Serious Infections Caused By Susceptible Anaerobic Bacteria ( 1.1 ) • Infections Due To Susceptible Strains Of Streptococci, Pneumococci And Staphylococci. ( 1.2 ) • Lower Respiratory Tract Infections. ( 1.3 ) • Skin And Skin Structure Infections. ( 1.4 ) • Gynecological Infections. ( 1.5 ) • Intra-Abdominal Infections. ( 1.6 ) • Septicemia. ( 1.7 ) • Bone And Joint Infections. ( 1.8 ) Limitation Of Use Since Clindamycin Does Not Diffuse Adequately Into The Cerebrospinal Fluid, Clindamycin In 0.9% Sodium Chloride Injection Should Not Be Used In The Treatment Of Meningitis ( 1.9 ) To Reduce The Development Of Drug-Resistant Bacteria And Maintain The Effectiveness Of Clindamycin In 0.9% Sodium Chloride Injection And Other Antibacterial Drugs, Clindamycin In 0.9% Sodium Chloride Injection Should Be Used Only To Treat Or Prevent Infections That Are Proven Or Strongly Suspected To Be Caused By Susceptible Bacteria. ( 1.10 ) 1.1 Infections Due To Susceptible Anaerobic Bacteria Clindamycin In 0.9% Sodium Chloride Injection Is Indicated For The Treatment Of Serious Infections Caused By Susceptible Anaerobic Bacteria [ See Indications And Usage (1.3 - 1.7) ]. 1.2 Infections Due To Susceptible Strains Of Streptococci, Pneumococci And Staphylococci Clindamycin In 0.9% Sodium Chloride Injection Is Indicated For The Treatment Of Serious Infections Due To Susceptible Strains Of Streptococci, Pneumococci, And Staphylococci. Its Use Should Be Reserved For Penicillin-Allergic Patients Or Other Patients For Whom, In The Judgment Of The Physician, A Penicillin Is Inappropriate. Because Of The Risk Of Antibacterial-Associated Pseudomembranous Colitis, [ See Boxed Warning ] , Before Selecting Clindamycin The Physician Should Consider The Nature Of The Infection And The Suitability Of Less Toxic Alternatives (E.g., Erythromycin). Bacteriologic Studies Should Be Performed To Determine The Causative Organisms And Their Susceptibility To Clindamycin. Indicated Surgical Procedures Should Be Performed In Conjunction With Antibacterial Therapy. 1.3 Lower Respiratory Tract Infections Clindamycin In 0.9% Sodium Chloride Injection Is Indicated In The Treatment Of Serious Lower Respiratory Tract Infections Including Pneumonia, Empyema, And Lung Abscess Caused By Susceptible Strains Of Anaerobes, Streptococcus Pneumoniae , Other Streptococci (Except E. Faecalis ), And Staphylococcus Aureus . 1.4 Skin And Skin Structure Infections Clindamycin In 0.9% Sodium Chloride Injection Is Indicated In The Treatment Of Serious Skin And Skin Structure Infections Caused By Susceptible Strains Of Streptococcus Pyogenes , Staphylococcus Aureus , And Anaerobes. 1.5 Gynecological Infections Clindamycin In 0.9% Sodium Chloride Injection Is Indicated In The Treatment Of Serious Gynecological Infections Including Endometritis, Nongonococcal Tubo-Ovarian Abscess, Pelvic Cellulitis, And Postsurgical Vaginal Cuff Infection Caused By Susceptible Anaerobes. 1.6 Intra-Abdominal Infections Clindamycin In 0.9% Sodium Chloride Injection Is Indicated In The Treatment Of Serious Intra-Abdominal Infections Including Peritonitis And Intra-Abdominal Abscess Caused By Susceptible Anaerobic Organisms. 1.7 Septicemia Clindamycin In 0.9% Sodium Chloride Injection Is Indicated In The Treatment Of Serious Septicemia Caused By Susceptible Strains Of Staphylococcus Aureus , Streptococci (Except Enterococcus Faecalis ), And Susceptible Anaerobes. 1.8 Bone And Joint Infections Clindamycin In 0.9% Sodium Chloride Injection Is Indicated In The Treatment Of Serious Bone And Joint Infections Including Acute Hematogenous Osteomyelitis Caused By Susceptible Strains Of Staphylococcus Aureus And As Adjunctive Therapy In The Surgical Treatment Of Chronic Bone And Joint Infections Due To Susceptible Organisms. 1.9 Limitations Of Use Since Clindamycin Does Not Diffuse Adequately Into The Cerebrospinal Fluid, Clindamycin In 0.9% Sodium Chloride Injection Should Not Be Used In The Treatment Of Meningitis [See Clinical Pharmacology (12.3) ] . 1.10 Usage To Reduce The Development Of Drug-Resistant Bacteria And Maintain The Effectiveness Of Clindamycin In 0.9% Sodium Chloride Injection And Other Antibacterial Drugs, Clindamycin In 0.9% Sodium Chloride Injection Should Be Used Only To Treat Or Prevent Infections That Are Proven Or Strongly Suspected To Be Caused By Susceptible Bacteria. When Culture And Susceptibility Information Are Available, They Should Be Considered In Selecting Or Modifying Antibacterial Therapy. In The Absence Of Such Data, Local Epidemiology And Susceptibility Patterns May Contribute To The Empiric Selection Of Therapy.
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