Molecular Excipient

163.0 -0.5 3 3 66.0 3 0.6
Present in 97 ZINC catalogs

Known Active Genes

There has not been any activity reported at 10μM or less for this excipient (per ChEBML)

Clinical Trials

This compound has been an intervention in the following clincial trials (per
Code Date Title Phase Status
NCT01021163 Effects of N-acetylcysteine on Pulmonary Function in High-risk Patients Undergoing Off-pump Coronary Bypass Surgery Phase 4 Completed
NCT02040818 2017-01-01 Treatment of Hemodialysis Catheter-Related Bacteremia Phase 2/Phase 3 Not Yet Recruiting
NCT02094625 2015-07-01 NAC to Prevent Cisplatin-induced Hearing Loss Phase 1 Not Yet Recruiting
NCT02357303 2015-03-01 Simethicone and N-acetylcysteine in Upper Endoscopy - Prospective Double-blinded Randomized Controlled Trial Phase 4 Not Yet Recruiting
NCT02362425 2015-01-01 Antioxidant Therapy in RYR1-Related Congenital Myopathy Phase 1/Phase 2 Recruiting
NCT02379637 2015-01-01 Study to Evaluate the Efficacy of N-acetylcysteine (NAC) in the Treatment of the Common Cold and Cough Phase 2 Recruiting
NCT02348775 2014-11-01 Glutathione and Function in HIV Patients Phase 1 Recruiting
NCT02348762 2014-11-01 Energetics and Function in Older Humans Phase 1 Recruiting
NCT02294591 2014-10-01 NACOS - The Effect of N-acetylcystein for Depressive Symptoms in Patients Suffering From Bipolar Depression Phase 2 Recruiting
NCT02269540 2014-10-01 A New Treatment Approach for Major Depressive Disorder Based Upon Targeting Monoamine Oxidase A (MAO-A) Phase 0 Recruiting
NCT02265224 2014-09-01 Bioequivalence Study of Two Different Formulations of N-acetyl-cysteine (NAC) Phase 1 Completed
NCT02212678 2014-09-01 Repeated-Dose Oral N-acetylcysteine for the Treatment of Parkinson's Disease Phase 2 Not Yet Recruiting
NCT02249546 2014-09-01 Efficacy of Acetylcysteine-containing Triple Therapy in the First Line of Helicobacter Pylori Infection Phase 4 Recruiting
NCT02171104 2014-07-01 MT2013-31:Allo BMT for Metabolic Disorders, Osteopetrosis and Males With Rett Syndrome Phase 2 Recruiting
NCT02141620 2014-05-01 n-Acetylcysteine and Cocaine Phase 0 Recruiting
NCT02182167 2014-05-01 A Trial Of Intravenous N-Acetylcysteine In The Management Of Antituberculous Drug-Induced Hepatitis Phase 2/Phase 3 Recruiting
NCT02088216 2014-03-01 Effect of Long-term, High-dose N-acetylcysteine on Exacerbations of Bronchiectaisis Phase 3 Active, Not Recruiting
NCT02335060 2014-03-01 N-acetylcysteine Effects on Tetrahydrocannabinol Phase 1 Recruiting
NCT02080182 2014-01-01 Effect of Acetylcysteine in Pediatric Acute Pyelonephritis. Phase 2 Recruiting
NCT01675661 2014-01-01 Achieving Cannabis Cessation-Evaluating N-Acetylcysteine Treatment Phase 3 Recruiting
NCT02357290 2014-01-01 Open-Label Study of N-Acetylcysteine in Children and Adolescents 5-17 With Bipolar Spectrum Disorders Phase 4 Recruiting
NCT01962961 2013-10-01 N-acetylcysteine to Reduce Oxidative Stress and Improve Endothelial Function in HIV-infected Older Adults Phase 1/Phase 2 Recruiting
NCT01993849 2013-10-01 Use of NAC in Fingernail Biting Phase 3 Recruiting
NCT02088502 2013-09-01 Theophylline, N-acetylcysteine, and Theophylline Plus N-acetylcysteine in Preventing Contrast-induced Nephropathy Phase 2/Phase 3 Recruiting
NCT02206178 2013-09-01 Acetaminophen's Antinociceptive Effect When Associated With N-Acetylcysteneine Phase 1 Recruiting
NCT01885338 2013-06-01 N-acetylcysteine (NAC) for Improving Cognitive Dysfunction in Schizophrenia Phase 1 Active, Not Recruiting
NCT01187108 2013-06-01 Study of Cobalt's Role in Excessive Erythrocytosis Among High Altitude Dwellers in Cerro de Pasco, Peru Phase 1/Phase 2 Completed
NCT01808521 2013-05-01 A Pilot Study of N-acetylcysteine in Thrombotic Thrombocytopenia Purpura Phase 0 Enrolling By Invitation
NCT01849016 2013-04-01 N-Acetylcysteine in Patients With Sickle Cell Disease Phase 3 Recruiting
NCT01800526 2013-03-01 A Pilot Study of N-acetylcysteine in Patients With Sickle Cell Disease Phase 0 Enrolling By Invitation
NCT01905696 2013-03-01 The Role of S-nitrosohemoglobin in Regulating Systemic Blood Flow During Hypoxia and Normoxia Phase 0 Active, Not Recruiting
NCT02124525 2013-02-01 N-acetylcysteine for Tobacco Smoking Phase 3 Recruiting
NCT01467466 2013-02-01 Prevention of Serious Adverse Events Following Angiography Phase 3 Recruiting
NCT01664260 2012-11-01 Efficacy Mechanism of N-acetylcysteine in Patients With Posttraumatic Stress Disorder Phase 2 Recruiting
NCT01726465 2012-11-01 Methylprednisolone N Acetylcysteine in Hepatic Resections Phase 2 Terminated
NCT01612221 2012-09-01 Oral N-acetylcysteine for Protection of Human Nevi Against UV-induced Oxidative Stress/Damage in Vivo Phase 2 Recruiting
NCT01753752 2012-09-01 Evaluation of the Corneal Residence Time of Chitosan-N-acetylcysteine Eye Drops in Patients With Dry Eye Syndrome After Single and Multiple Instillation Phase 2 Completed
NCT01172275 2012-07-01 N-acetylcysteine (NAC) for Pediatric Obsessive-Compulsive Disorder Phase 2 Recruiting
NCT01653171 2012-07-01 Premedication With Simethicone or Simethicone Plus N-acetylcysteine in Improving Visibility During Upper Endoscopy Phase 4 Completed
NCT01878695 2012-07-01 Pilot Study of Anti-oxidant Supplementation With N-Acetyl Cysteine in Stage 0/I Breast Cancer Phase 1 Recruiting
NCT01555970 2012-03-01 Efficacy Study of add-on Therapy With N-Acetylcysteine in Resistant Obsessive-compulsive Disorder Phase 2 Completed
NCT01439828 2012-02-01 Clinical Trial of N-acetylcysteine Versus Placebo Efficacy in the Cannabis Withdrawal Phase 2 Not Yet Recruiting
NCT01537926 2012-01-01 Hypertrophic Regression With N-Acetylcysteine in HCM Phase 1 Recruiting
NCT01470027 2012-01-01 N-Acetylcysteine for Neuroprotection in Parkinson's Disease Phase 1/Phase 2 Recruiting
NCT01424033 2011-12-01 Evaluating N-Acetylcysteine in CTD-ILD Treatment Phase 2/Phase 3 Recruiting
NCT01501110 2011-11-01 Effects of N-acetylcysteine on Low T3 Syndrome Phase 4 Recruiting
NCT01866644 2011-09-01 Effectiveness of N-acetylcysteine ​​on Preservation Solution During Liver Transplantation Phase 3 Recruiting
NCT01495260 2011-09-01 A Clinical Trial for AMN: Validation of Biomarkers of Oxidative Stress, Efficacy and Safety of a Mixture of Antioxidants Phase 2 Completed
NCT01427517 2011-07-01 Intravenous N-acetylcysteine for the Treatment of Gaucher's Disease and Parkinson's Disease Phase 1 Completed
NCT01747616 2011-07-01 Assessment of Safety and Tolerability of Chitosan-N-acetylcysteine Eye Drops in Subjects While Wearing Contact Lenses and Before Insertion of Contact Lenses Phase 1 Completed
NCT01384591 2011-07-01 Pilot Study of Losartan and N-acetylcysteine as Inhibitors of Muscle Oxidative Stress in Elderly Phase 1/Phase 2 Active, Not Recruiting
NCT01232257 2011-07-01 Effect of N-acetylcysteine (NAC) on Hydrogen Sulfide (H2S) in Chronic Kidney Disease (CKD) Phase 3 Completed
NCT01572597 2011-06-01 Increased Re-eradication Rate of Helicobacter Pylori by Adding N-acetylcystein or Metronidazole to the Triple Therapy Phase 4 Recruiting
NCT01354132 2011-05-01 N-Acetyl-Cysteine (NAC) in Early Phase Schizophrenia Spectrum Psychosis Phase 4 Recruiting
NCT01278784 2011-03-01 Local Tolerability of Chitosan-N-acetylcysteine Eye Drops in Healthy Young Volunteers Phase 1 Completed
NCT01111734 2011-03-01 Early Study of N-Acetylcysteine to Treat Deliberate Self-Harm in Adolescents Phase 1 Recruiting
NCT01704482 2011-02-01 N-acetylcysteine for Renal Protection in Patients With Rheumatic Heart Disease Undergoing Valve Replacement Phase 2 Completed
NCT01265563 2011-01-01 Glutathione in Diabetic Nephropathy Phase 2 Recruiting
NCT01251029 2011-01-01 Effect of N-acetylcysteine on Renal Functioning of Chronic Kidney Diseases(CKD) Patients After General Anesthesia Phase 1 Not Yet Recruiting
NCT01741207 2011-01-01 Effect of N-acetylcystein in Myocardial Infarction Phase 3 Recruiting
NCT02168387 2010-12-01 Efficacy of Percussive Ventilation Therapy (MetaNeb ®) Compared With Mucolytic Agents for Atelectasis in the Mechanically Ventilated Pediatric Patient Phase 4 Completed
NCT01214083 2010-10-01 N-acetylcysteine Plus Naltrexone for the Treatment of Alcohol Dependence Phase 2 Recruiting
NCT01381354 2010-10-01 Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS) Phase 1 Active, Not Recruiting
NCT01015209 2010-09-01 Safety and Tolerability of Chitosan-N-acetylcysteine Eye Drops in Healthy Young Volunteers Phase 1 Completed
NCT01050270 2010-09-01 Scottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning Study (SNAP) Phase 4 Completed
NCT01118663 2010-09-01 Safety and Efficacy Study of a New Formulation of Acetylcysteine Injection Phase 3 Terminated
NCT01394419 2010-09-01 Effect of N-acetylcysteine on Prevention of Acute Kidney Injury in High Risk Patients Undergoing Off-pump Coronary Artery Bypass Graft Phase 4 Completed
NCT01355198 2010-08-01 Role of HIV on Glutathione Synthesis and Oxidative Stress Phase 1 Completed
NCT01172288 2010-07-01 N-acetylcysteine (NAC) for Children With Tourette Syndrome Phase 2 Completed
NCT01271088 2010-06-01 Protective Effect of N-acetylcysteine Against From Ototoxicity Phase 2/Phase 3 Completed
NCT01138137 2010-06-01 N-acetylcysteine Given IV With Cisplatin and Paclitaxel in Patients With Ovarian Cancer Phase 1 Suspended
NCT01063205 2010-03-01 NAC as a Potential Treatment for Methamphetamine Dependence Phase 1 Completed
NCT01111422 2010-03-01 Anti-Oxidant Effect on Peritoneal Membrane in Peritoneal Dialysis (PD) Patients Phase 4 Recruiting
NCT01131572 2010-02-01 N-acetylcysteine in Bulimia Nervosa Phase 2/Phase 3 Terminated
NCT00996424 2010-01-01 The Effect of Inhaled N-Acetylcysteine Compared to Normal Saline on Sputum Rheology and Lung Function Phase 4 Terminated
NCT01033149 2009-12-01 N-acetylcysteine in the Treatment of Bulimia Nervosa Phase 3 Terminated
NCT00650091 2009-10-01 Evaluating the Effectiveness of Prednisone, Azathioprine, and N-acetylcysteine in Patients With IPF Phase 3 Completed
NCT00915200 2009-10-01 N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy Phase 2 Recruiting
NCT01210456 2009-10-01 Efficacy Trial of N-Acetylcysteine and Sodium Bicarbonate for the Prevention of Contrast-Induced Acute Kidney Injury Phase 3 Enrolling By Invitation
NCT00993265 2009-10-01 N-Acetylcysteine for Pediatric Trichotillomania Phase 2 Completed
NCT01005810 2009-09-01 A Trial of N-Acetylcysteine (an Over-the-Counter Medicine) in Adolescents Who Smoke Marijuana Phase 2 Recruiting
NCT01082445 2009-08-01 Effects of N-acetylcysteine on Diabetic Foot Oxygenation Phase 3 Completed
NCT00775476 2009-03-01 Treatment of Systemic Lupus Erythematosus (SLE) With N-acetylcysteine Phase 1/Phase 2 Suspended
NCT00969904 2009-03-01 Pilot Study to Assess the Effect of High Dose N-acetylcysteine (NAC) in Chronic Obstructive Pulmonary Disease (COPD) Patients Phase 4 Completed
NCT00870883 2009-03-01 N-acetylcysteine Plus Deferoxamine for Patients With Hypotension Phase 2 Recruiting
NCT01017796 2009-01-01 Contrast Agent-associated Nephrotoxicity in Intensive Care Unit Patients Phase 0 Active, Not Recruiting
NCT00896025 2008-12-01 Study of N-Acetylcysteine in Acute Liver Failure (ALF) Phase 4 Terminated
NCT00809094 2008-11-01 NAC Phase IIB: A Multi-Center, Phase IIB, Randomized, Placebo-controlled, Double-Blind Study Of The Effects Of N-Acetylcysteine On Redox Changes and Lung Inflammation In Cystic Fibrosis Patients Phase 2 Completed
NCT00724594 2008-08-01 Safety of N-acetylcysteine in Maternal Chorioamnionitis (NAC in Chorio) Phase 1/Phase 2 Recruiting
NCT00736866 2008-08-01 The Acetylcysteine for Contrast-Induced Nephropathy Trial Phase 3 Completed
NCT00716001 2008-07-01 Effect of Hydration With Sodium Bicarbonate for Long-Term Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing an Emergent Coronary Procedure Phase 4 Not Yet Recruiting
NCT01131468 2008-02-01 Prevention of Drug Induced Ototoxicity in Peritoneal Dialysis Patients by N-Acetylcysteine Phase 2 Completed
NCT00558142 2008-02-01 Mechanisms for the Effect of Acetylcysteine on Renal Function After Exposure to Radiographic Contrast Material Phase 4 Recruiting
NCT00542750 2008-01-01 An Open-Label Trial of N-Acetylcysteine in Cannabis Dependent Adolescents Phase 1/Phase 2 Completed
NCT00568087 2007-12-01 N-acetylcysteine in Alcohol Dependence Phase 1/Phase 2 Completed
NCT00483314 2007-11-01 Homocystinuria: Treatment With N-Acetylcysteine Phase 2 Completed
NCT00575419 2007-11-01 Safety Study Of N-Acetylcysteine For Prevention Of Contrast Induced Nephropathy In Patients w/Stage 3 Renal Failure Phase 1 Recruiting
NCT00552786 2007-11-01 Antioxidation Medication for Noise-induced Hearing Loss Phase 2 Completed
NCT00506506 2007-10-01 Effect of N-Acetylcysteine (NAC) on Creatinine in Chronic Kidney Disease Phase 3 Completed
NCT00532688 2007-09-01 N-Acetylcysteine in Heart Failure With Coexistent Chronic Renal Failure Phase 2/Phase 3 Recruiting
NCT00539188 2007-09-01 N-Acetylcysteine in Adjunct to DBT for the Treatment of Self-Injurious Behavior in BPD Phase 2 Terminated
NCT00525551 2007-09-01 Efficacy of Acetylcysteine in Patients Undergoing Surgery for Otosclerosis Phase 4 Completed
NCT00497328 2007-08-01 COmbined N-acetylcysteine and Bicarbonate in PCI To Reduce Adverse Side Effect of contrasT Phase 2/Phase 3 Completed
NCT00655928 2007-08-01 Modulation of Lung Injury Complicating Lung Resection Phase 2 Completed
NCT00568113 2007-07-01 N-Acetyl Cysteine for Prevention of Preterm Birth Phase 4 Completed
NCT00476736 2007-05-01 The Effect of N-Acetylcystein on Quality of Life and Air Trapping During Rest and After Exercise Phase 4 Recruiting
NCT00467831 2007-04-01 Pilot Study of a Multi-Drug Regimen for Severe Pulmonary Fibrosis in Hermansky-Pudlak Syndrome Phase 1/Phase 2 Terminated
NCT00440869 2007-03-01 Effects of N-acetylcysteine on Muscle Fatigue in Hemodialysis Phase 1 Completed
NCT00453180 2007-03-01 A Study of Oral N-Acetylcysteine in Children With Autism Spectrum Disorders Phase 2 Completed
NCT00556465 2007-01-01 Efficacy of N-Acetylcysteine in Treatment of Overt Diabetic Nephropathy Phase 2/Phase 3 Completed
NCT00428883 2007-01-01 High Dose Intravenous N-Acetylcysteine Versus Iloprost for Early, Rapidly Progressive Diffuse Systemic Sclerosis Phase 2/Phase 3 Recruiting
NCT00463749 2006-12-01 Myocardial Salvage and Contrast Dye Induced Nephropathy Reduction by N-Acetylcystein Phase 3 Completed
NCT01394497 2006-12-01 Use of N-Acetylcysteine During Liver Procurement Phase 2 Completed
NCT00751257 2006-12-01 N-Acetylcysteine and Smoking Reduction Phase 2 Completed
NCT00391911 2006-11-01 Study of N-Acetylcysteine (NAC) and Continuous Renal Replacement Therapy (CRRT) for the Treatment of Rhabdomyolysis Phase 2 Completed
NCT00397735 2006-10-01 N-acetylcysteine in Intra-amniotic Infection/Inflammation Phase 1/Phase 2 Recruiting
NCT00614679 2006-10-01 A Novel Catheter Lock Solution for Treatment of Tunneled Hemodialysis Catheter-Associated Bacteremia Phase 1 Recruiting
NCT00998972 2006-09-01 N-acetyl-cysteine (NAC) and Kidney Graft Function Phase 3 Completed
NCT00539513 2006-06-01 N-Acetylcysteine Augmentation in Treatment-Refractory Obsessive-Compulsive Disorder Phase 2 Terminated
NCT00337038 2006-06-01 Endothelial Function as a Marker for Blood Pressure Control Among Hypertensive Diabetic Patients Phase 0 Completed
NCT00808795 2006-04-01 Efficacy of N-Acetylcysteine in Prevention of Post-Catheterization Contrast-Induced Nephropathy in Diabetic Patients With Chronic Kidney Disease Phase 3 Completed
NCT00267384 2006-03-01 N-acetylcysteine Protects From Aminoglycosides Induced Nephrotoxicity Phase 2/Phase 3 Completed
NCT00611897 2006-01-01 N-acetylcysteine and NMDA Antagonist Interactions Phase 1/Phase 2 Completed
NCT00512265 2006-01-01 Influence of N-Acetylcysteine on Morbidity, Oxygenation and Cytokine Levels in Partial or Total Esophagectomy for Cancer Phase 4 Completed
NCT00218491 2005-11-01 Effectiveness of N-Acetylcysteine (NAC) in Treating Cocaine Dependent Individuals - 1 Phase 2 Completed
NCT00247507 2005-09-01 The Effects of Acetylcysteine on Alleviating Damage of Oxidative Stress in Hemodialysis Patients Phase 4 Active, Not Recruiting
NCT00374088 2005-02-01 N-Acetylcysteine in Neonatal Congenital Heart Surgery (INACT Study) Phase 2 Completed
NCT00356954 2005-02-01 NASPI: N-Acetylcysteine vs. Ascorbic Acid for Prevention of Contrast Induced Nephropathy in Renal Insufficiency Undergoing Coronary Catheterization Phase 4 Completed
NCT00569465 2005-01-01 N-Acetylcysteine and Arginine Administration in Diabetic Patients Phase 4 Terminated
NCT00190034 2005-01-01 Acetylcysteine Against Acute Renal Insult During Cardiopulmonary Bypass. Phase 4 Suspended
NCT00238173 2004-12-01 Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With Malignant Brain Tumors Phase 1 Suspended
NCT00203099 2004-12-01 Safety and Efficacy Study of Copaxone Administered in Combination With N-Acetylcysteine Phase 2 Completed
NCT00332631 2004-08-01 High-Dose N-Acetylcysteine in Cardiac Surgery Phase 2 Completed
NCT00187330 2004-03-01 A Study of The Effectiveness of N-Acetylcysteine in Kidney Protection Following Cardiopulmonary Bypass Phase 2 Completed
NCT00188773 2004-01-01 Mechanism of Fatty Acid-Induced Impairment of Glucose-Stimulated Insulin Secretion Phase 4 Completed
NCT00196885 2003-12-01 Effect of an Antioxidant on Cancer-Cachectic Patients Undergoing Exercise Training Phase 2 Completed
NCT00188630 2003-07-01 N-Acetylcysteine for Preventing Renal Injury After Cardiac Surgery Phase 3 Completed
NCT00211653 2003-04-01 Acetylcysteine in the Prevention of Renal Failure After Bypass Surgery Phase 1/Phase 2 Completed
NCT00136825 2003-03-01 Effectiveness of N-Acetylcysteine in Treating Cocaine Dependent Individuals - 1 Phase 1 Completed
NCT00237614 2003-02-01 Contrast Nephropathy Prevention With N-Acetylcysteine in Acute Myocardial Infarction Phase 2/Phase 3 Completed
NCT01223326 2003-01-01 N-acetylcysteine to Reduce Ischemia/Reperfusion Injury in Liver Resection Phase 4 Completed
NCT00830193 2002-08-01 N-Acetylcysteine in Critically Ill Patients Undergoing Contrast Enhanced Computed Tomography Phase 2/Phase 3 Completed
NCT01771978 2002-06-01 Ischaemia-réperfusion During the Coronary Surgery With Beating Heart Phase 3 Active, Not Recruiting
NCT00122018 2002-05-01 An Investigation of N-acetylcysteine and Fenoldopam as Renal Protection Agents for Cardiac Surgery Phase 2 Completed
NCT00492518 2002-02-01 Acetylcysteine, Theophylline, and a Combination of Both in the Prophylaxis of Contrast-Induced Nephropathy Phase 4 Completed
NCT00962442 2000-09-01 N-Acetylcysteine in Severe Acute Alcoholic Hepatitis Phase 3 Completed
NCT00639496 2000-03-01 Study of the Effects of High-dose N-acetylcysteine (NAC) in Idiopathic Pulmonary Fibrosis (IPF) Phase 3 Completed
NCT00248625 2000-01-01 A Multi-center Study of the Safety and Efficacy of N-acetylcysteine in the Treatment of Acute Liver Failure in Pediatric Patients Not Caused by Acetaminophen. Phase 3 Completed
NCT00184977 1998-12-01 COPD on Primary Care Treatment (COOPT) Phase 4 Completed
NCT00004467 1998-06-01 Randomized Study of Acetylcysteine in Patients With Acute Liver Failure Not Caused by Acetaminophen Phase 3 Completed
NCT00003346 1997-11-01 Combination Chemotherapy in Treating Patients With Stage III or Stage IV Melanoma Phase 2 Completed

(Browse) Purchasable Analogs in ZINC


Route Formulation Per Unit Dose
Inhalation Solution 0.5%

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